Analysis software for QuantiFERON SARS-CoV-2 RUO is available for download.
Research publications indicating the use of T cell assays in severity assessment and monitoring of individuals
1. Rydyznski Moderbacher, C. et al., (2020) Antigens-specific adaptive immunity to SARS-CoV-2 in acute COVID-19 and associations with age and disease severity. Cell 183, 1–17.
2. Candon, S. et al., (2020) T cell and antibody responses to SARS-CoV-2: experience from a French transplantation and hemodialysis center during the COVID-19 pandemic. Am J Transplant doi:10.1111/ajt.16348
3. Han, M. et al., (2020) Assessing SARS-CoV-2 RNA levels and lymphocyte/T cell counts in COVID-19 patients revealed initial immune status as a major determinant of disease severity. Med Microbiol Immunol 209, 657–668.
4. Iqbal, H. (2020) The importance of cell-mediated immunity in COVID-19 – An opinion. Medical Hypotheses 143, 110152.
5. Liu, B. et al., (2020) Reduced numbers of T cells and B cells correlates with persistent SARS-CoV-2 presence in non-severe COVID-19 patients. Sci Rep 10, 17718.
6. Petrone, L. et al., (2020) A whole blood test to measure SARS-CoV-2 specific response in COVID-19 patients. Clin Microbiol Infect https://doi.org/10.1016/j.cmi.2020.09.051
7. Stephens, D.S. and McElrath, M.J. (2020) COVID-19 and the path to immunity. JAMA 324 (13), 1279–1281.
8. Zhang, B., Yue, D., Wang, Y., Wang, F., Wu, S. and Hou, H. (2020) The dynamics of immune response in COVID‐19 patients with different illness severity. J Med Virol https://doi.org/10.1002/jmv.26504.
9. Poonia, B. and Kottilil, S. (2020) Immune correlates of COVID-19 control. Front Immunol 11, 569611. doi: 10.3389/fimmu.2020.569611
Research publications indicating the use of T cell assays in vaccine efficacy, epidemiology survey and protective immunity assessment
10. Grifoni, A. et al., (2020) Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals. Cell 181, 1489–1501.
11. Murugesan, K. et al., (2020) Interferon-gamma release assay for accurate detection of SARS-CoV-2 T cell response. Clin Infect Dis, ciaa1537, https://doi.org/10.1093/cid/ciaa1537
12. Sauer, K. and Harris, T. (2020) An Effective COVID-19 vaccine needs to engage T cells. Front Immunol 11, 2371.
13 Oladipo, E.K. et al., (2020) Exploration of surface glycoprotein to design multi-epitope vaccine for the prevention of Covid-19. Inform Med Unlocked 21, 100438, https://doi.org/10.1016/j.imu.2020.100438
14. Cox, R.J. and Brokstad, K.A. (2020) Not just antibodies: B cells and T cells mediate immunity to COVID-19. Nat Rev Immunol 20, 581–582.
15. Mateus, J. et al., (2020) Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans. Science 370 (6512), 89–94.
16. de Vries, R.D. (2020) SARS-CoV-2-specific T-cells in unexposed humans: presence of cross-reactive memory cells does not equal protective immunity. Sig Transduct Target Ther 5, 224.
17. Peng, Y. et al., (2020) Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19. Nat Immunol 21, 1336–1345.
18. Petrone, L., et al., (2020) A whole blood test to measure SARS-CoV-2 specific response in COVID-19 patients. Clin Microbiol Infect https://doi.org/10.1016/j.cmi.2020.09.051.
19. Weiskopf, D. et al., (2020) Phenotype and kinetics of SARS-CoV-2-specific T-cells in COVID-19 patients with acute respiratory distress syndrome. Sci Immunol 5 (48), doi: 10.1126/sciimmunol.abd2071
20. Sekine, T. et al., (2020) Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19. Cell 183 (1), 158–168 E14.