Wound Healing & Fibrosis

Wound Healing & Fibrosis
Find more about Wound Healing & Fibrosis
Wound healing progresses via 3 overlapping phases: inflammation, granulation, and tissue remodeling. After cutaneous injury, a blood clot forms, and inflammatory cells infiltrate the wound, secreting cytokines and growth factors to initiate the inflammation phase. During the granulation phase, fibroblasts and other cells differentiate into myofibroblasts, which deposit extracellular matrix (ECM) proteins. Simultaneously, angiogenesis occurs, and keratinocytes proliferate and migrate to close the wound. In the final tissue remodeling phase, apoptosis eliminates myofibroblasts and extraneous blood vessels, and the ECM is remodeled to resemble the original tissue. Fibrosis occurs when inappropriate tissue remodeling results in excess ECM deposition due to myofibroblast survival or lack of ECM proteolytic degradation. At the other extreme of wound healing pathophysiology, chronic wounds feature dysregulated tissue remodeling with enhanced ECM degradation. As wound healing and its dysregulation via fibrosis and other means occur in all tissues, analysis of these mechanisms may yield novel drug targets for a variety of disorders. ...
Read more
Wound healing progresses via 3 overlapping phases: inflammation, granulation, and tissue remodeling. After cutaneous injury, a blood clot forms, and inflammatory cells infiltrate the wound, secreting cytokines and growth factors to initiate the inflammation phase. During the granulation phase, fibroblasts and other cells differentiate into myofibroblasts, which deposit extracellular matrix (ECM) proteins. Simultaneously, angiogenesis occurs, and keratinocytes proliferate and migrate to close the wound. In the final tissue remodeling phase, apoptosis eliminates myofibroblasts and extraneous blood vessels, and the ECM is remodeled to resemble the original tissue. Fibrosis occurs when inappropriate tissue remodeling results in excess ECM deposition due to myofibroblast survival or lack of ECM proteolytic degradation. At the other extreme of wound healing pathophysiology, chronic wounds feature dysregulated tissue remodeling with enhanced ECM degradation. As wound healing and its dysregulation via fibrosis and other means occur in all tissues, analysis of these mechanisms may yield novel drug targets for a variety of disorders.

QIAGEN provides a broad range of assay technologies for wound healing and fibrosis research that enables analysis of gene expression and regulation, epigenetic modification, genotyping, and signal transduction pathway activation. Solutions optimized for wound healing and fibrosis studies include PCR array, miRNA, siRNA, mutation analysis, pathway reporter, chromatin IP, DNA methylation, and protein expression products.
  • Description
RT² Profiler PCR Array
The Human Wound Healing RT² Profiler PCR Array profiles the expression of 84 key genes central to the wound healing response. Wound healing progresses via three overlapping phases: inflammation,...

Show details
Species
Human
Cat. no.
PAHS-121Z
RT² Profiler PCR Array
The Mouse Wound Healing RT² Profiler PCR Array profiles the expression of 84 key genes central to the wound healing response. Wound healing progresses via three overlapping phases: inflammation,...

Show details
Species
Mouse
Cat. no.
PAMM-121Z
RT² Profiler PCR Array
The Rat Wound Healing RT² Profiler PCR Array profiles the expression of 84 key genes central to the wound healing response. Wound healing progresses via three overlapping phases: inflammation,...

Show details
Species
Rat
Cat. no.
PARN-121Z
RT² Profiler PCR Array
The Human Fibrosis RT² Profiler PCR Array profiles the expression of 84 key genes involved in dysregulated tissue remodeling during the repair and healing of wounds. Wound healing consists of...

Show details
Species
Human
Cat. no.
PAHS-120Z
RT² Profiler PCR Array
The Mouse Fibrosis RT² Profiler PCR Array profiles the expression of 84 key genes involved in dysregulated tissue remodeling during the repair and healing of wounds. Wound healing consists of...

Show details
Species
Mouse
Cat. no.
PAMM-120Z
RT² Profiler PCR Array
The Rat Fibrosis RT² Profiler PCR Array profiles the expression of 84 key genes involved in dysregulated tissue remodeling during the repair and healing of wounds. Wound healing consists of three...

Show details
Species
Rat
Cat. no.
PARN-120Z
Multi-Analyte  ELISArray Kit
The Human Inflammatory Cytokines & Chemokines Multi-Analyte ELISArray Kit analyzes a panel of 12 pro-inflammatory cytokines using a conventional ELISA protocol all at once under uniform...

Show details
Species
Human
Cat. no.
MEH-004A
Multi-Analyte  ELISArray Kit
The Mouse Inflammatory Cytokines & Chemokines Multi-Analyte ELISArray Kit analyzes a panel of 12 pro-inflammatory cytokines using a conventional ELISA protocol all at once under uniform...

Show details
Species
Mouse
Cat. no.
MEM-004A
Multi-Analyte  ELISArray Kit
The Rat Inflammatory Cytokines & Chemokines Multi-Analyte ELISArray Kit analyzes a panel of 12 pro-inflammatory cytokines using a conventional ELISA protocol all at once under uniform conditions....

Show details
Species
Rat
Cat. no.
MER-004A
Show more
Show Less