TGFb / BMP Signaling
Find more about TGFb / BMP Signaling
The TGFβ superfamily comprises 4 signaling pathways: TGFβ, Bone Morphogenic Protein (BMP), Activin, and Nodal. This family of secreted proteins regulates immune function, cell proliferation, and epithelial to mesenchymal transition. BMPs play roles in embryogenesis as well as tissue and organ morphogenesis, whereas TGFβ signaling regulates cell growth and differentiation. Activin and Nodal signaling are also involved in cellular development. Activation of TGFβ cytokines occurs via proteolytic cleavage of their precursors, and their signaling results in activation of SMAD dependent and independent transcription. Many genes are targets of TGFβ activation, including genes involved in cell adhesion, apoptosis, and developmental processes. Dysregulation of TGF signal transduction is associated with a number of diseases including fibrosis and cancer. ...
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The TGFβ superfamily comprises 4 signaling pathways: TGFβ, Bone Morphogenic Protein (BMP), Activin, and Nodal. This family of secreted proteins regulates immune function, cell proliferation, and epithelial to mesenchymal transition. BMPs play roles in embryogenesis as well as tissue and organ morphogenesis, whereas TGFβ signaling regulates cell growth and differentiation. Activin and Nodal signaling are also involved in cellular development. Activation of TGFβ cytokines occurs via proteolytic cleavage of their precursors, and their signaling results in activation of SMAD dependent and independent transcription. Many genes are targets of TGFβ activation, including genes involved in cell adhesion, apoptosis, and developmental processes. Dysregulation of TGF signal transduction is associated with a number of diseases including fibrosis and cancer.

QIAGEN provides a broad range of assay technologies for TGFβ / BMP signaling research that enables analysis of gene expression and regulation, epigenetic modification, genotyping, and signal transduction pathway activation. Solutions optimized for TGFβ / BMP signaling studies include PCR array, miRNA, siRNA, mutation analysis, pathway reporter, chromatin IP, DNA methylation, and protein expression products.
  • Description
RT² Profiler PCR Array
The Human TGFß / BMP Signaling Pathway RT² Profiler PCR Array profiles the expression of 84 genes related to TGFß / BMP-mediated signal transduction. The array includes members of the TGFß...

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Species
Human
Cat. no.
PAHS-035Z
RT² Profiler PCR Array
The Mouse TGFß / BMP Signaling Pathway RT² Profiler PCR Array profiles the expression of 84 genes related to TGFß / BMP-mediated signal transduction. The array includes members of the TGFß...

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Species
Mouse
Cat. no.
PAMM-035Z
RT² Profiler PCR Array
The Rat TGFß / BMP Signaling Pathway RT² Profiler PCR Array profiles the expression of 84 genes related to TGFß / BMP-mediated signal transduction. The array includes members of the TGFß...

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Species
Rat
Cat. no.
PARN-035Z
RT² Profiler PCR Array
The Human TGFß Signaling Targets RT² Profiler PCR Array profiles the expression of 84 key genes responsive to TGFß signal transduction. The TGFß superfamily comprises 4 signaling pathways: TGFß,...

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Species
Human
Cat. no.
PAHS-235Z
RT² Profiler PCR Array
The Mouse TGFß Signaling Targets RT² Profiler PCR Array profiles the expression of 84 key genes responsive to TGFß signal transduction. The TGFß superfamily comprises 4 signaling pathways: TGFß,...

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Species
Mouse
Cat. no.
PAMM-235Z
RT² Profiler PCR Array
The Rat TGFß Signaling Targets RT² Profiler PCR Array profiles the expression of 84 key genes responsive to TGFß signal transduction. The TGFß superfamily comprises 4 signaling pathways: TGFß,...

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Species
Rat
Cat. no.
PARN-235Z
Cignal Reporter Assay Kit
The Cignal SMAD Reporter Assay Kit is designed to monitor the activity of the TGFβ-induced signal transduction pathway in cultured cells. The transforming growth factor β (TGFβ) signaling pathway...

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Species
Luciferase
Cat. no.
CCS-017L
Cignal Reporter Assay Kit
The Cignal SMAD Reporter Assay Kit is designed to monitor the activity of the TGFβ-induced signal transduction pathway in cultured cells. The transforming growth factor β (TGFβ) signaling pathway...

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Species
GFP
Cat. no.
CCS-017G
Cignal Lenti Reporter Assay
The Cignal Lenti Reporter Assays are self-inactivating replication incompetent viral particles. The lentiviral particles are ready to add directly to your cells. The Cignal Lenti SMAD Reporter is...

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Species
Luciferase
Cat. no.
CLS-017L
Single-Analyte ELISArray Kit
The Human TGFB1 Single Analyte ELISArray Kit is designed to quantitatively measure the amount of this cytokine in cell culture supernatant, serum or plasma using a conventional enzyme-linked...

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Species
Human
Cat. no.
SEH00508A
Single-Analyte ELISArray Kit
The Mouse TGFB1 Single Analyte ELISArray Kit is designed to quantitatively measure the amount of this cytokine in cell culture supernatant, serum or plasma using a conventional enzyme-linked...

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Species
Mouse
Cat. no.
SEM02991A
EpiTect Methyl II Complete PCR array (96)
The Human TGFβ/BMP Signaling Pathway EpiTect Methyl II Signature PCR Array profiles the promoter methylation status of a panel of 22 promoters of genes involved in TGFβ and BMP-mediated signaling...

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Species
Human
Cat. no.
EAHS-351Z
EpiTect ChIP qPCR Array
The Human TGFβ/BMP Signaling Pathway EpiTect ChIP qPCR Array profiles the histone modification status or “histone code” of 84 genes related to TGFß and BMP-mediated signaling during...

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Species
Human
Cat. no.
GH-035A
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