Extracellular Matrix & Adhesion Molecules

Extracellular Matrix & Adhesion Molecules
Find more about Extracellular Matrix & Adhesion Molecules
Cells attach to proteoglycans and glycoproteins on the surface of other cells as well as in the extracellular matrix (ECM) substratum via adhesion molecules to define tissue shape, structure, and function. Making and breaking cellular contacts with other cells and the ECM play critical roles in normal processes such as cell growth, division, differentiation, and migration. Cardiovascular and central nervous system disorders and pathophysiological processes such as fibrosis and inflammation require ECM remodeling. Remodeling involves expression of different cell adhesion molecules, altering cellular processes such as migration and polarity. Key ECM proteins include fibronectin, laminin, and collagens as well as metalloproteinases that remodel the ECM. Important cell adhesion genes include integrins, selectins, celladhesion molecule family members (ICAM, ECAM, NCAM, PECAM, and VCAM), and the catenins which link cell adhesion molecules and the cytoskeleton. Analysis of these essential genes may identify novel mechanisms in ECM remodeling and dysregulation. ...
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Cells attach to proteoglycans and glycoproteins on the surface of other cells as well as in the extracellular matrix (ECM) substratum via adhesion molecules to define tissue shape, structure, and function. Making and breaking cellular contacts with other cells and the ECM play critical roles in normal processes such as cell growth, division, differentiation, and migration. Cardiovascular and central nervous system disorders and pathophysiological processes such as fibrosis and inflammation require ECM remodeling. Remodeling involves expression of different cell adhesion molecules, altering cellular processes such as migration and polarity. Key ECM proteins include fibronectin, laminin, and collagens as well as metalloproteinases that remodel the ECM. Important cell adhesion genes include integrins, selectins, celladhesion molecule family members (ICAM, ECAM, NCAM, PECAM, and VCAM), and the catenins which link cell adhesion molecules and the cytoskeleton. Analysis of these essential genes may identify novel mechanisms in ECM remodeling and dysregulation.

QIAGEN provides a broad range of assay technologies for extracellular matrix and adhesion molecule research that enable analysis of gene expression and regulation, epigenetic modification, genotyping, and signal transduction pathway activation. Solutions optimized for extracellular matrix and adhesion molecule studies include PCR array, miRNA, siRNA, mutation analysis, pathway reporter, chromatin IP, DNA methylation, and protein expression products.
  • Description
RT² Profiler PCR Array
The Human Extracellular Matrix & Adhesion Molecules RT² Profiler PCR Array profiles the expression of 84 genes important for cell-cell and cell-matrix interactions. Cells attach to proteoglycans...

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Species
Human
Cat. no.
PAHS-013Z
RT² Profiler PCR Array
The Mouse Extracellular Matrix & Adhesion Molecules RT² Profiler PCR Array profiles the expression of 84 genes important for cell-cell and cell-matrix interactions. Cells attach to proteoglycans...

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Species
Mouse
Cat. no.
PAMM-013Z
RT² Profiler PCR Array
The Rat Extracellular Matrix & Adhesion Molecules RT² Profiler PCR Array profiles the expression of 84 genes important for cell-cell and cell-matrix interactions. Cells attach to proteoglycans and...

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Species
Rat
Cat. no.
PARN-013Z
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